منابع مشابه
Ion Channels: A physiological function for polyamines?
It is now recognized that polyvalent organic cations, such as polyamines, can act as endogenous modifiers of ion-channel gating, properties which were previously assumed to be entirely intrinsic to the channel proteins. All cells possess myriad different ion channels, which span their plasma membranes. These proteins are usually made up of four or five subunits, which together form an ion-perme...
متن کاملInteractions of polyamines with ion channels.
Endogenous polyamines, in particular spermine, have been found to cause block and modulation of a number of types of ion channel. Intracellular spermine is responsible for intrinsic gating and rectification of strong inward rectifier K+ channels by directly plugging the ion channel pore. These K+ channels control the resting membrane potential in both excitable and non-excitable cells, and cont...
متن کاملInfluence of polyamines on membrane functions.
Polyamines (putrescine, spermidine and spermine) are ubiquitous polycationic metabolites in prokaryotic and eukaryotic cells. Their roles in the regulation of major functions in cell growth, cell differentiation and their intricate and exquisitely regulated biosynthetic pathways have attracted considerable attention during the last few decades. Authoritative reviews and books have dealt with th...
متن کاملIon channels in sperm physiology.
Fertilization is a matter of life or death. In animals of sexual reproduction, the appropriate communication between mature and competent male and female gametes determines the generation of a new individual. Ion channels are key elements in the dialogue between sperm, its environment, and the egg. Components from the outer layer of the egg induce ion permeability changes in sperm that regulate...
متن کاملInteraction Mechanisms between Polyamines and IRK1 Inward Rectifier K+ Channels
Rectification of macroscopic current through inward-rectifier K+ (Kir) channels reflects strong voltage dependence of channel block by intracellular cations such as polyamines. The voltage dependence results primarily from the movement of K+ ions across the transmembrane electric field, which accompanies the binding-unbinding of a blocker. Residues D172, E224, and E299 in IRK1 are critical for ...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2021
ISSN: 1422-0067
DOI: 10.3390/ijms22010441